Sunanda Kotagiri

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We report a case of spinal muscle atrophy type 1 (Werdnig-Hoffman disease) with a complex congenital heart malformation. Heart involvement in spinal muscle atrophy (SMA) is virtually unknown. In fact, congenital heart disease was at one stage regarded as an exclusion criterion in the diagnosis of SMA [6]. A male infant was admitted to the special care baby(More)
A heterologous gene probe encoding the alpha and beta subunits of the Pseudomonas cepacia protocatechuate 3,4-dioxygenase (PCD) was used to detect its homolog in the genome of Bradyrhizobium japonicum USDA110. Three cosmid clones carrying a 2.2-kb BamHI insert showed high levels of PCD activity. SacI digestion of one of the genomic clones, pBjG17, produced(More)
The structure and function of the human alcohol dehydrogenase 7 (ADH7) promoter were analyzed. A promoter fragment extending to bp -232 functioned well in H4IIE-C3, CV-1, and HeLa cells, whereas the region extending further upstream to bp -799 had no significant effect on activity. We identified cis-acting elements in the proximal 232 bp and examined their(More)
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