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BACKGROUND The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to several diseases. Studies on association between VDR polymorphisms and risk of type 2 diabetes (T2DM) in different ethnic populations are yet inconclusive. AIMS This study was conducted to evaluate association between VDR polymorphisms and genetic susceptibility to T2DM(More)
Type II diabetes mellitus (T2DM) is a common and serious metabolic disorder worldwide. It is the third leading cause of death after cancer and cardiovascular disease (CVD). Over time, diabetes mellitus can lead to different complications like atherosclerosis, coronary heart disease and many micro- and macrovascular diseases. CD36 is a class B scavenger(More)
Type 2 diabetes (T2DM) is a noncommunicable disease affecting huge populations in India and abroad. Single-nucleotide polymorphisms (SNPs) in CD36, a macrophage scavenger receptor, have been implicated in the pathogenesis of T2DM and its complications. Eleven SNPs in the CD36 gene and their association with 100 each of control subjects and T2DM patients(More)
BACKGROUND & OBJECTIVES The greater tendency to diabetes in Indians may be due to genetic factors in addition to environment and diet. CD36, a class B scavenger cell surface receptor mediates internalization of oxidized low density lipoprotein (Ox-LDL) leading to the formation of macrophage foam cells. CD36 deficiency is related to phenotypic expression of(More)
BACKGROUND Type 2 diabetes mellitus (T2DM) is a multifactorial disease resulting from ineffective use of insulin in the body. Single nucleotide polymorphisms (SNPs) in genes for scavenger receptors such as CD36 have been implicated in the pathogenesis of atherosclerosis and cardiovascular diseases in diabetes. The present study evaluated the effect of(More)
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