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A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases
There is growing evidence of shared risk alleles for complex traits (pleiotropy), including autoimmune and neuropsychiatric diseases. This might be due to sharing among all individuals (whole-groupExpand
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Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires between aExpand
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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
To define potentially causal variants for autoimmune disease, we fine-mapped1,2 76 rheumatoid arthritis (11,475 cases, 15,870 controls)3 and type 1 diabetes loci (9,334 cases, 11,111 controls)4.Expand
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Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4[superscript +] Effector Memory T Cells
Genome-wide association studies (GWAS) and subsequent dense-genotyping of associated loci identified over a hundred single-nucleotide polymorphism (SNP) variants associated with the risk ofExpand