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BACKGROUND PARP inhibitors have shown promising clinical results in cancer patients carrying BRCA1/2 mutations. Their clinical efficacy could logically be influenced by PARP1 protein levels in patient tumors. METHODS We screened three cohorts of patients with ovarian cancer, totaling 313 samples, and evaluated PARP1 protein expression by(More)
Hypoxia-ischemia (HI) brain injury is a major cause of neuronal cell death especially apoptosis in the perinatal period. This study was designated to examine the effect of hydrogen therapy on apoptosis in an established neonatal HI rat pup model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min hypoxia (8% oxygen(More)
Aimed at tracking precision of a certain electromotive power loading simulator for actuator with uncertainties and external disturbance, a new design approach of an adaptive fuzzy sliding mode controller (AFSMC) for nonlinear systems with mismatched time-varying uncertainties is presented in this paper. An adaptive parameters adjuster and fuzzy control(More)
In terms of the demands on environment monitoring, by taking monitoring the area polluted and weather environment as application background, temperature and humidity etc as inspecting parameters, tiny wireless sensor network nodes are designed, the node took the MSP430 ultra low power MCU as the core, and used 2.4G CC2420 RF chip, the solution and(More)
We have developed a new bioartificial liver bioreactor filled with porcine hepatocytes immobilized on polyester nonwoven fabric (NWF). In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for perfusion treatment in a canine liver failure model.(More)
OBJECTIVE (i) To determine whether clinical features and biochemical parameters help to predict survival of methylmalonic acidemia with homocystinuria; (ii) To find the cutoff values of biochemical parameters for predicting survival of methylmalonic acidemia with homocystinuria. DESIGN A prospective cohort study. SETTING A pediatric tertiary hospital in(More)
OBJECTIVE To evaluate the clinical value of fine needle aspiration cytology (FNAC) for breast cancer surgery. METHODS FNAC was performed in 530 patients highly suspected of breast cancer from January 2004 to January 2009 in Peking Union Medical College Hospital. The FNAC-positive cases received radical operation directly, while the negative cases received(More)
OBJECTIVE To evaluate the impact of lesion size on the detection rate of non-palpable breast malignant lesions and determine whether lesion size should prompt biopsy of non-palpable breast lesions. METHODS The study included 816 ultrasonographically detected non-palpable breast lesions. We divided the lesions into five groups based on their largest(More)
CONTEXT Tumor-like inflammatory demyelinating disease (TIDD) usually occurs in the brain and rarely occurs in the spinal cord. TIDD appears to be very similar to tumors such as gliomas on imaging, which may lead to incorrect or delayed diagnosis and treatment. CASE REPORT Because of headache and incoherent speech, a 24-year-old Chinese male presented to(More)
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