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Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.
TLDR
Among ginsenoside R(c) and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines. Expand
Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.
TLDR
Ginsenoside Rg3 and its metabolites exhibited the most potent cytotoxicity against tumor cell lines, 20(S)- and 20(R)-protopanaxadiols potently inhibited the growth of Helicobacter pylori, and 20 (S)-ginsenoside Rh2 inhibited H+/K+ ATPase of rat stomach. Expand
Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment.
TLDR
The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein. Expand
Anti-amnesic effect of Chong-Myung-Tang on scopolamine-induced memory impairments in mice.
TLDR
Results suggest that CMT may be useful for the cognitive improvement via regulation of cholinergic marker enzyme activities and the antioxidant defense system. Expand
Genotoxic Effects of Nonylphenol and Bisphenol A Exposure in Aquatic Biomonitoring Species: Freshwater Crustacean, Daphnia magna, and Aquatic Midge, Chironomus riparius
TLDR
Investigation of the geno-, and eco-toxicity of nonlyphenol and bisphenol A and BPA in Daphnia magna and Chironomus riparius found DNA damage in these species could provide useful information. Expand
Purification and Characterization ofα -l-Arabinopyranosidase andα -l-Arabinofuranosidase from Bifidobacterium breve K-110, a Human Intestinal Anaerobic Bacterium Metabolizing Ginsenoside Rb2 and Rc
TLDR
It is suggested that the biochemical properties and substrate specificities of these purified enzymes are different from those of previously purified α-l-arabinosidases. Expand
Geno- and Ecotoxicity Evaluation of Silver Nanoparticles in Freshwater Crustacean Daphnia magna
TLDR
Genotoxic- and ecotoxic assessments of silver nanoparticles (AgNPs) were conducted on the freshwater crustacean Daphnia magna, suggesting that AgNPs are slightly more toxic than Ag ions. Expand
The Rho-Kinase (ROCK) Inhibitor Y-27632 Protects Against Excitotoxicity-Induced Neuronal Death In Vivo and In Vitro
TLDR
Results indicate that ROCK inhibition modulates neurite growth and protects neurons from excitotoxicity-induced cell death. Expand
miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells.
TLDR
Findings indicate that miR-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics. Expand
Lovastatin increases longitudinal bone growth and bone morphogenetic protein-2 levels in the growth plate of Sprague-Dawley rats
TLDR
Lovastatin increases longitudinal bone growth and bone morphogenetic protein-2 levels in the growth plate of Sprague-Dawley rats and may have implications for the treatment of children, as well as promoting bone growth in normal adolescent rats. Expand
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