Sun Young Chae

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Some characteristics of vertical optokinetic nystagmus and after-nystagmus, in particular, its up/down gain asymmetry, are known to be influenced by gravity direction, which is basically perceived by otolith organs. However, how such an information of gravity direction is processed within the central nervous system is not well understood, even though the(More)
OBJECTIVE Spatial normalization of C-Pittsburgh Compound B (PiB) images is challenging for an automatic quantitative analysis without magnetic resonance imaging (MRI) because of different distribution patterns between amyloid positive and negative images. To overcome this issue, we evaluated a selective positron emission tomography template (SPT) method. (More)
In addition to angular acceleration, eccentric rotation (ECR) imparts linear acceleration to the head positioned eccentric to the axis of rotation. Using ECR in squirrel monkeys, the effects of otolith organ stimulation by linear acceleration on vestibulo-ocular reflex (VOR) gain were investigated. With the animal's head facing away from the rotation axis,(More)
The enhancement of the vestibulo-ocular reflex (VOR) gain in the eccentric rotation is mediated by the otolith organs. Functional recovery of the otolith-ocular reflex after deafferentation of the otolith organs was examined in squirrel monkeys, using the enhancement of the eccentric VOR gain as an indicator of the reflex. After unilateral deafferentation(More)
To evaluate the direction-specific effect of optokinetic storage function on balance compensation after unilateral labyrinthectomy, squirrel monkeys (n = 12) were exposed to a prolonged (30 min) daily optokinetic stimulus (horizontal, constant speed-90 degrees/sec) for 14 days; either in the ipsilateral direction to the slow phase of spontaneous nystagmus,(More)
In this study, we have shown the potential of a voxel-based analysis for imaging amyloid plaques and its utility in monitoring therapeutic response in Alzheimer's disease (AD) mice using manganese oxide nanoparticles conjugated with an antibody of Aβ1-40 peptide (HMON-abAβ40). T1-weighted MR brain images of a drug-treated AD group (n=7), a nontreated AD(More)
Structural reorganization in white matter (WM) after stroke is a potential contributor to substitute or to newly establish the functional field on the injured brain in nature. Diffusion tensor imaging (DTI) is an imaging modality that can be used to evaluate damage and recovery within the brain. This method of imaging allows for in vivo assessment of the(More)
When a subject is rotated around an axis located behind his head (eccentric rotation, ECR), he experiences a combination of angular acceleration and two kinds of linear accelerations, tangential and centrifugal. The effects of stimulation of the otolith organs by linear acceleration in ECR on gain of the vestibulo-ocular reflex (VOR) were examined in(More)
To assess the dynamic changes of the autonomic neural responses evoked by vestibular-visual conflict (VVC) in the squirrel monkey, we analyzed the changes of salivary amount and sodium concentration, and the coefficient of variance (CV) of R-R intervals (RRI) along the time course of VVC exposure given in pitch plane. The sodium concentration and the amount(More)
Modifications in the vertical vestibulo-ocular reflex (VVOR) were studied in four squirrel monkeys (Saimiri sciureus) over time after unilateral labyrinthectomy. In the dark, with head upright, animals were exposed to sinusoidal rotation in the pitch plane. The magnetic field-pericorneal search coli technique was used to detect eye movement. The upward and(More)
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