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Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.

• Sun-Hee Kim, Kwang Seok Ahn, +10 authors Sung-Hoon Kim
• European journal of pharmacology
• 2011

Although the flavonoid icariside II exhibits anti-inflammatory and anti-cancer activities, its molecular targets/pathways in human multiple myeloma cells are poorly understood. To analyze the effects… (More)

Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway.

• Suk-Hyun Won, Hyo-Jeong Lee, +10 authors Sung-Hoon Kim
• Biological & pharmaceutical bulletin
• 2010

Tanshinone IIA (Tan IIA; 14,16-epoxy-20-nor-5(10),6,8,13,15-abietapentaene-11,12-dione), a phytochemical derived from the roots of Salvia miltiorrhiza BUNGE, has been reported to posses… (More)

Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells.

• Ji-Hyun Kim, Soo-Jin Jeong, Bonglee Kim, Sun-Mi Yun, D. Y. Choi, Sung-Hoon Kim
• Journal of pineal research
• 2012

To evaluate melatonin's ability to enhance ovarian cancer cells to cisplatin treatment for ovarian cancer, this study was performed. Melatonin by itself had no significant cytotoxicity against… (More)

Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells

• Chan-Hee Lee, Soo-Jin Jeong, +10 authors Sung-Hoon Kim
• Proteome Science
• 2010

Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables that exerts anti-oxidant, anti-inflammatory, anti-cancer and radio-sensitizing activities. Nonetheless, the mechanism… (More)

Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells.

• Sun-Mi Yun, Ji Hoon Jung, Soo-Jin Jeong, Eun Jung Sohn, Bonglee Kim, Sung-Hoon Kim
• Phytotherapy research : PTR
• 2014

Although tanshinone IIA (Tan IIA) from Salviae miltiorrhizae was known to induce apoptosis in various cancers, its underlying mechanism of autophagic cell death was not reported yet. Thus, in the… (More)

Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells.

• Sun-Mi Yun, Kyung Hee Jung, +6 authors Soon-Sun Hong
• Cancer letters
• 2013

The RAF/MEK/ERK and PI3K/AKT pathways are highly implicated in the development of pancreatic cancer. The principal objective of this study was to assess the synergic effect between Sorafenib (a RAF… (More)

Cryptotanshinone enhances TNF-α-induced apoptosis in chronic myeloid leukemia KBM-5 cells

• Ji-Hyun Kim, Soo-Jin Jeong, +8 authors Sung-Hoon Kim
• Apoptosis
• 2011

Cryptotanshinone is a biologically active compound from the root of Salvia miltiorrhiza. In the present study, we investigated the molecular mechanisms by which cryptotanshinone is in synergy with… (More)

Activation of c-Jun N-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells.

• Sun-Mi Yun, Soo-Jin Jeong, +5 authors Sung-Hoon Kim
• Biological & pharmaceutical bulletin
• 2013

Aim of this study was to identify the molecular mechanisms of tanshinone IIA-induced apoptosis in chronic myelogenous leukemia (CML) cells. Cytotoxicity of tanshinone IIA was evaluated by… (More)

Protective effect of Bojungbangdocktang on cisplatin-induced cytotoxicity and apoptosis in MCF-10A breast endothelial cells.

• Sang-Hun Kang, Hyo-Jung O. Lee, +9 authors Sung-Hoon Kim
• Environmental toxicology and pharmacology
• 2009

Although cisplatin has been extensively used as a cancer chemotherapeutic agent for the treatment of various human cancers, it causes significant side effects such as nephrotoxicity and… (More)

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells

• Sun-Mi Yun, Sang Hyeok Woo, +11 authors I. -S. Park
• Molecular and Cellular Endocrinology
• 2016

Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we… (More)

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