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SUMO1 modulates Aβ generation via BACE1 accumulation
TLDR
This study indicates SUMO1 is not only a novel and potent regulator of BACE1 accumulation and Aβ generation but also a potential therapeutic target for Alzheimer's disease. Expand
Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
TLDR
Results indicate that fisetin reduces levels of phosphorylated tau through the autophagy pathway activated by TFEB and Nrf2 and should be evaluated further as a potential preventive and therapeutic drug candidate for AD. Expand
A high-throughput assay of NK cell activity in whole blood and its clinical application.
TLDR
A simple assay that uses whole blood instead of PBMC or isolated NK cells to detect interferon (IFN)-γ secreted from NK cells as an indicator of NKA is developed and used as a supportive diagnostic marker for microsatellite stable (MSS) colorectal cancer patients. Expand
Sulforaphane induces autophagy through ERK activation in neuronal cells
TLDR
Evidence is provided that SFN‐mediated generation of reactive oxygen species (ROS) induces autophagy with increased levels of LC3‐II through extracellular signal‐regulated kinase (ERK) activation in neuronal cells, independent of Nrf2 activity in neurons. Expand
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke
TLDR
It is demonstrated that ACE2 expression is increased in ischemic brains and vessels exposed to diabetes or smoking, makes them vulnerable to COVID-19 infection. Expand
Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation*
TLDR
The results suggest that mitogen-activated protein kinase kinase 1 activated in differentiating myoblasts stimulates muscle differentiation by phosphorylating MyoD-Y156, which results in MyOD stabilization. Expand
VEGFR2 alteration in Alzheimer’s disease
TLDR
Results indicate that the alterations of VEGF and its two receptors levels might be associated with those at risk for Alzheimer’s disease. Expand
Altered expression of Notch1 in Alzheimer's disease
TLDR
Results indicate that altered expression of Notch1 might be associated with the risk of Alzheimer’s disease. Expand
Elevation of plasma soluble amyloid precursor protein beta in Alzheimer's disease.
TLDR
The results suggest that individuals with elevated plasma sAPPβ levels are at an increased risk of AD; elevation in these levels may reflect the progression of disease. Expand
SUMO1 promotes Aβ production via the modulation of autophagy
TLDR
The results suggest that SUMO1 accelerates the accumulation of AVs and promotes Aβ production, which is a key mechanism for understanding the AV-mediated pathophysiology of Alzheimer disease. Expand
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