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Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss.
TLDR
Harpagoside inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro and suppresses inflammation-induced bone loss in a mouse model, suggesting that HAR is a valuable agent against inflammation-related bone disorders but not osteoporosis induced by hormonal abnormalities. Expand
Dual Effect of Chrysanthemum indicum Extract to Stimulate Osteoblast Differentiation and Inhibit Osteoclast Formation and Resorption In Vitro
TLDR
Investigation of Chrysanthemum indicum extract (CIE) on the differentiation of osteoclastic and osteoblastic cells revealed that CIE could have a potential therapeutic role in bone-related disorders through its dual effects on osteoclast and osteoblast differentiation. Expand
Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway.
TLDR
The results indicate for the first time that esculetin inhibits RANKL-mediated osteoclastogenesis via direct suppression of c-Fos and NFATc1 expression and exerts an inhibitory effect on actin ring formation during osteOClastogenesis. Expand
Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c‐Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice
TLDR
PCA inhibits RANKL‐induced osteoclast differentiation and function by suppressing JNK signaling, c‐Fos stability, and expression of osteoclastic marker genes, suggesting that PCA could be useful in treatment of inflammatory bone disorders. Expand
Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells.
TLDR
The inhibition of the amine oxidase activity of LOX significantly suppressed both mineral nodule formation and the expression of osteoblast marker genes during the differentiation of primary calvaria cells, suggesting that the LOX-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteOBlastogenesis. Expand
Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1
TLDR
Findings suggest that S. hexaphylla might be useful for the development of new anti-osteoporosis agents. Expand
Relationship Between Serum Calcium and Magnesium Concentrations and Metabolic Syndrome Diagnostic Components in Middle-Aged Korean Men
TLDR
Serum Ca had positive association with TG and BP, while serum Mg had negative association with serum glucose after adjusting age and BMI among the middle-aged Korean male adults. Expand
Dissipation pattern and risk quotients assessment of amisulbrom in Korean melon cultivated in plastic house conditions
TLDR
The current data indicate that the amisulbrom can be applied safely to Korean melon; hence, it is unlikely to induce adverse health effects in consumers. Expand
Aconitum pseudo-laeve var. erectum Inhibits Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclastogenesis via the c-Fos/nuclear Factor of Activated T-Cells, Cytoplasmic 1 Signaling
TLDR
It is demonstrated that APE restores LPS-induced bone loss through a decrease of the serum RANKL/OPG ratio, and inhibits osteoclast differentiation and function, suggesting the promise of APE as a potential cure for various osteOClast-associated bone diseases. Expand
Ampelopsis brevipedunculata Extract Prevents Bone Loss by Inhibiting Osteoclastogenesis in Vitro and in Vivo
TLDR
Results demonstrate that ABE prevents LPS-induced bone erosion through inhibition of osteoclast differentiation and function, suggesting the promise of ABE as a potential cure for various osteocline-associated bone diseases. Expand
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