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Speculative execution, such as control speculation and data speculation, is an effective way to improve program performance. Using edge/path profile information or simple heuristic rules, existing compiler frameworks can adequately incorporate and exploit control speculation. However, very little has been done so far to allow existing compiler frameworks to(More)
The effects of removing chondroitin sulfate from chondroitin sulfate proteoglycan molecules on guidance of retinal ganglion cell axons at the optic chiasm were investigated in a brain slice preparation of mouse embryos of embryonic day 13 to 15. Slices were grown for 5 hours and growth of dye-labeled axons was traced through the chiasm. After continuous(More)
This paper addresses the problems of representing aliases and indirect memory operations in SSA form. We propose a method that prevents explosion in the number of SSA variable versions in the presence of aliases. We also present a technique that allows indirect memory operations to be globally commonized. The result is a precise and compact SSA(More)
Using quantitative immunoblotting, we have measured the level of two mammalian neurofilament proteins, the 68-kDa NF-L and the 66-kDa NF-66 (alpha-internexin), in the rat CNS during development. NF-66 is localized in neurons and neuronal processes in both embryonic and postnatal brain. Importantly, NF-66 is more abundant than NF-L in both forebrain and(More)
A new algorithm, SSAPRE, for performing partial redundancy elimination based entirely on SSA form is presented. It achieves optimal code motion similar to lazy code motion [KRS94a, DS93], but is formulated independently and does not involve iterative data flow analysis and bit vectors in its solution. It not only exhibits the characteristics common to other(More)
The SSAPRE algorithm for performing partial redundancy elimination based entirely on SSA form is presented. The algorithm is formulated based on a new conceptual framework, the factored redundancy graph, for analyzing redundancy, and representes the first sparse approach to the classical problem and on methods for its solution. With the algorithm(More)
Intravitreal injection of N-methyl-D-aspartate (NMDA) produced a substantial damage to the adult rat retina that was largely restricted to inner retinal layers, including the ganglion cell layer (GCL), inner nuclear layer (INL), inner, and outer plexiform layers. This retinal damage was significantly reduced by a systemic injection of a low dose of MK-801(More)
Retinal cell death induced by over-stimulation of glutamate receptors is related to the programmed cell death or apoptosis. However, little is known about the intracellular events that lead to this cell death process in the retina. In this study, we asked if caspase-3 family cysteine proteases regulate cell death in an explant culture of adult rat retina(More)
Retinoic acid (RA) induces P19 embryonal carcinoma cells to differentiate into neurons with the extension of neuritic processes. We used the P19 cell as a model system to elucidate the regulation of neurofilament (NF) expression. Four mammalian NF proteins, NF-66 (alpha-internexin), peripherin, NF-L and NF-M, and the neural-specific, growth-associated gene,(More)