Sumita Chanan

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BACKGROUND Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis-regulatory elements based on constrained sequence evolution. However, these methods fail to detect functional elements that are too weakly conserved among mammals to distinguish them from non-functional DNA. RESULTS To evaluate a strategy for(More)
BACKGROUND Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. RESULTS In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor.(More)
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. LDL receptor enhancer evolution <p>Analysis of primate-specific evolution of the LDL receptor enhancer demonstrates a molecular mechanism by which ancestral mam-malian regulatory elements can evolve to perform new functions.</p> Background:(More)
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