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OBJECTIVE To assess the efficacy and safety of topiramate and lamotrigine for prophylaxis in patients with frequent migraine as compared to each other and to placebo. METHODS Sixty patients with frequent migraine (more than 4 attacks per month) from the headache clinic at a tertiary referral centre in India were randomized to receive 50 mg(More)
OBJECTIVES Sleep related complaints and rapid eye movement (REM) behavior disorder (RBD) are commonly reported in patients with Parkinson's disease (PD). The study aimed to compare the characteristics of patients with PD with RBD versus those without RBD. METHODS Consecutive patients with PD were evaluated with detailed clinical history, examination and(More)
OBJECTIVES To investigate the association of (i) seven SNPs and SNP haplotypes in the phase II conjugating enzyme N-acetyl transferase 2 gene; and (ii) slow acetylator phenotype, with the development of young onset (YO) and late onset (LO) Parkinson's disease (PD) among Indians. METHODS A total of 267 cases (132 YOPD, age at onset < or =40 years; 135(More)
Parkinson's disease (PD) is a debilitating neurodegenerative disorder affecting 1.5% of all above 55 years of age. Sleep related complaints are commonly reported in patients with PD and may form an important determinant of their quality of life. Interactions among genetic and environmental factors may play an important role in the development of and also(More)
AIMS Muscle biopsy is an important diagnostic modality and screening test for the diagnosis of dystrophinopathies. Sometimes muscle biopsies are needed for the diagnosis when genetic tests are inconclusive and are also useful for immunoblotting assay of the dystrophin protein. However, the procedure is painful, requires anesthesia and sometimes needs to be(More)
BACKGROUND Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutation in the gene encoding for calpain-3 resulting in total or partial loss of protein. Diagnosis of LGMD2A, the most prevalent form of LGMD, is established by analyzing calpain-3 protein deficiency or CAPN3 gene mutation. Since there is no data from India regarding the incidence of(More)
Tubular aggregate myopathy (TAM) is a rare form of myopathy with an autosomal dominant or recessive pattern. Four rare cases of TAM are described. All patients presented with muscle aches and pains, sometimes cramps. Muscle biopsies were snap frozen and processed for routine, special, enzyme, and immunohistochemistry. Tissue was also processed for electron(More)
CONTEXT Muscle biopsy is at present the gold standard for the diagnosis of idiopathic inflammatory myopathies (IIMs), which include dermatomyositis, polymyositis, and inclusion body myositis. Currently, there is no definite diagnostic marker that helps in the discrimination of different subgroups of IIMs and the discrimination of IIMs from other clinical(More)