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- Jason R. Hickok, Sumit Sahni, +4 authors Douglas S. Thomas
- Free radical biology & medicine
- 2011
It is well established that nitric oxide ((•)NO) reacts with cellular iron and thiols to form dinitrosyliron complexes (DNIC). Little is known, however, regarding their formation and biological fate.… (More)
- Jason R. Hickok, Sumit Sahni, Yuliya Mikhed, Marcelo Gialluisi Bonini, Douglas S. Thomas
- The Journal of biological chemistry
- 2011
N-Myc downstream-regulated gene 1 (NDRG1) is a ubiquitous cellular protein that is up-regulated under a multitude of stress and growth-regulatory conditions. Although the exact cellular functions of… (More)
- Angelica M. Merlot, Sumit Sahni, +9 authors Danuta S. Kalinowski
- Oncotarget
- 2015
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that 14C-Dp44mT enters and targets cells through a… (More)
- Sukriti Krishan, Des. R. Richardson, Sumit Sahni
- Molecular pharmacology
- 2015
Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor, which once activated, plays a role in several processes within the cell to restore energy homeostasis. The protein… (More)
- Angelica M. Merlot, Danuta S. Kalinowski, +5 authors Des. R. Richardson
- Future medicinal chemistry
- 2015
Albumin is the most abundant protein in human blood with concentrations ranging from 34 to 50 mg/ml [1]. This protein is well known to bind to a range of endogenous and exogenous molecules [1]. For… (More)
- Sumit Sahni, Angelica M. Merlot, Sukriti Krishan, Patric J. Jansson, Des. R. Richardson
- Journal of clinical pathology
- 2014
The BECN1 gene encodes the Beclin-1 protein, which is a well-established regulator of the autophagic pathway. It is a mammalian orthologue of the ATG6 gene in yeast and was one of the first… (More)
- Patric J. Jansson, Tetsuo Yamagishi, +7 authors Des. R. Richardson
- The Journal of biological chemistry
- 2015
Multidrug resistance (MDR) is a major obstacle in cancer treatment. More than half of human cancers express multidrug-resistant P-glycoprotein (Pgp), which correlates with a poor prognosis.… (More)
- Sumit Sahni, D K Bae, Patric J. Jansson, Des. R. Richardson
- Pharmacological research
- 2017
Autophagy is an evolutionary conserved cellular catabolic degradation process in response to stress which involves lysosomal degradation of unnecessary or damaged organelles and misfolded proteins.… (More)
- Jasmina Paluncic, Žaklina Kovačević, +7 authors Des. R. Richardson
- Biochimica et biophysica acta
- 2016
Melanoma has markedly increased worldwide during the past several decades in the Caucasian population and is responsible for 80% of skin cancer deaths. Considering that metastatic melanoma is almost… (More)
- Tetsuo Yamagishi, Sumit Sahni, Danae M. Sharp, A. Arvind, Patric J. Jansson, Des. R. Richardson
- The Journal of biological chemistry
- 2013
Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little work has… (More)