Learn More
PURPOSE The aim of this study is to develop novel polylactide/poly(ethylene glycol) (PLA/PEG) micelles as carrier of hydrophobic drug (paclitaxel) by direct dissolution method without using any organic solvents. The in vitro and in vivo release properties were studied in comparison with micelles prepared by dialysis. METHODS Drug encapsulation efficiency(More)
Synthetic polymers have attracted much attention in tissue engineering due to their ability to modulate biomechanical properties. This study investigated the feasibility of processing poly(epsilon-caprolactone) (PCL) homopolymer, PCL-poly(ethylene glycol) (PEG) diblock, and PCL-PEG-PCL triblock copolymers into three-dimensional porous scaffolds. Properties(More)
Recently, a novel gene-deletion method was developed for the crenarchaeal model Sulfolobus islandicus, which is a suitable tool for addressing gene essentiality in depth. Using this technique, we have investigated functions of putative DNA repair genes by constructing deletion mutants and studying their phenotype. We found that this archaeon may not encode(More)
Poly(epsilon-caprolactone) (PCL) and its block copolymers with poly(ethylene glycol) (PEG) were prepared by ring-opening polymerization of epsilon-caprolactone in the presence of ethylene glycol or PEG, using zinc metal as catalyst. The resulting polymers were characterized by various analytical techniques such as (1)H NMR, SEC, DSC, IR, X-ray, ESEM, and(More)
Ring-opening polymerization of D,L-lactide was carried out in the presence of monohydroxylated poly(ethylene glycol) (PEG) with Mn of 2000 and 5000, using zinc powder as catalyst. The resulting PEG-b-polylactide (PEG-PLA) diblocks with various ethylene oxide/lactyl (EO/LA) ratios were coupled with adipoyl chloride to yield PEG-PLA-PEG triblock copolymers.(More)
Copolymers of polylactide (PLA) and poly(ethylene glycol) (PEG) were synthesized by ring-opening polymerization of L- or D-lactide in the presence of mono- or dihydroxyl PEG using nontoxic zinc lactate as catalyst. The resulting diblock and triblock copolymers were characterized by various analytical techniques such as SEC, (1)H NMR, XRD, and DSC.(More)
A series of copolymers with various compositions were synthesized by bulk ring-opening polymerization of glycolide and epsilon-caprolactone, using stannous (II) octoate or zirconium (IV) acetylacetonate as initiator. Reaction time and temperature were varied so as to induce different chain microstructures. The resulting copolymers were characterized by (1)H(More)
A series of glycolide/epsilon-caprolactone copolymers were compression molded and allowed to degrade in a pH 7.4 phosphate buffer at 37 degrees C. Degradation was monitored by various analytical techniques such as (1)H NMR, X-ray diffraction, DSC, CZE, ESI-MS, and inherent viscosity measurements. The results show that the degradation rate depends not only(More)
Degradable copolymers were synthesized by ring opening polymerization of lactide in the presence of poly(ethylene glycol) (PEG), using CaH2 as a biocompatible initiator. The resulting PLA/PEO/PLA triblock copolymers were dissolved in a biocompatible solvent, namely tetraglycol. Physically crosslinked hydrogels were then prepared by introducing small amounts(More)
Poly(epsilon-caprolactone) was blended with various polylactide-based polymers and processed to films by the solution casting method. Blends of 25/75, 50/50, 75/25, 90/10, and 95/5 (w/w) poly(epsilon-caprolactone)/poly(l-lactide), a 95/5 (w/w) blend of poly(epsilon-caprolactone) with a poly(d-lactide), a 50/50 (w/w) poly(l-lactide)-poly(d-lactide) mixture,(More)