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Elevated peripheral levels of interleukin-6 (IL-6) are common findings in schizophrenia and depression. However, previous studies that measured cerebrospinal fluid (CSF) IL-6 levels in these disorders reported controversial results. The present study examined whether CSF IL-6 levels are altered in patients with schizophrenia and those with depression.(More)
Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genome-wide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder(More)
We have observed epileptic seizures of juvenile myoclonic epilepsy (JME) to be surprisingly sensitive to higher mental activity. The purpose of the present study was to examine changes over time in seizure susceptibility in two patients with JME who we followed-up for over 20 years. During the period, they were repeatedly subjected to provocative cognitive(More)
Impulsivity is a key feature of disorders that include attention-deficit/hyperactivity disorder (ADHD). The cliff avoidance reaction (CAR) assesses maladaptive impulsive rodent behavior. Dopamine transporter knockout (DAT-KO) mice display features of ADHD and are candidates in which to test other impulsive phenotypes. Impulsivity of DAT-KO mice was assessed(More)
BACKGROUND The present study was designed to assess, using event-related potentials, whether aberrant semantic processing reported in schizophrenia results from primary semantic overactivation or contextual dysregulation. METHODS The visual event-related brain potentials were compared between 9 schizophrenic subjects and 16 normal control subjects(More)
BACKGROUND Accumulating evidence indicates that oxytocin plays an important role in social interactions. Previous studies also suggest altered oxytocin function in patients with schizophrenia and depression. However, few studies have examined the central oxytocin levels in these disorders. METHODS Cerebrospinal fluid (CSF) oxytocin levels were measured by(More)
Amino acids play key roles in the function of the central nervous system, and their alterations are implicated in psychiatric disorders. In the search for a biomarker for major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino acids and related molecules in the cerebrospinal fluid (CSF) of 52 patients with MDD (42(More)
Fischer 344 (F344) and Lewis (LEW) rats differ in physiological regulation of the limbic-hypothalamo-pituitary-adrenal (LHPA) axis, such that F344 rats exhibit greater LHPA axis responses to a variety of stimuli. Furthermore, LHPA axis activity has been implicated in the development of sensitization to abused drugs, and F344 rats exhibit greater behavioral(More)
The aim of the present study was to examine the region-specific correlations between electroencephalography (EEG) dimensional complexity (DC), a measure of non-linear dynamics, and neuropsychological performance in 25 right-handed patients with Alzheimer's disease (AD). Electroencephalography recording sites were according to the international 10-20 system.(More)
1. The effects of subchronic methamphetamine (MAP) treatment and restraint stress on the behavioral sensitization in stereotypy (stereotypy sensitization) and cliff avoidance reaction (CAR) were examined in two inbred strains of male rats; Fischer 344/N (F344), and Lewis/N (LEW). 2. In experiment 1, the animals received 4 mg/kg/day MAP for 30 days. LEW rats(More)