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An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.
IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice
Both IL-25 and IL-33 are critical for induction of Th2-type cytokine-mediated allergic airway eosinophilia, but not Th17-type influenza-mediated airway neutrophilia, at the local sites of lungs in the challenge phase of mice sensitized EC with OVA.
Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells.
IL-33 induces functional CCR7 expression in human mast cells.
Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs
Findings indicate the adjuvant activity of chitin via a new mechanism and provide important clues for development of therapeutics for allergic disorders caused by HDM, fungi and crustaceans.
Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells
A method of differentiating peripheral neurons from human induced pluripotent stem cells (hiPSCs) for physiological study of itch resulted in the robust induction of p75 and HNK1 double-positive NC cells from hiPSCs, and these peripheral neurons included sensory neurons responsive to itch-related stimuli.
Human eosinophils constitutively express a unique serine protease, PRSS33.
Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
- Sumika Toyama, M. Tominaga, K. Takamori
- BiologyInternational Journal of Molecular Sciences
- 1 November 2021
Current knowledge of immune cell-derived itch mediators and neuronal response mechanisms are summarized, and therapeutic agents that target these systems are discussed.
Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes.