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Because available data suggest that resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) is increasing in Nepal, an open-label, parallel-group efficacy/safety study was conducted in 99 Nepalese patients with uncomplicated falciparum malaria randomized 2:1 to artemetherlumefantrine (AL) or SP. Efficacy was assessed from clinical and(More)
BACKGROUND Cataract and glaucoma are the major causes of blindness in Nepal. Bhaktapur is one of the three districts of Kathmandu valley which represents a metropolitan city with a predominantly agrarian rural periphery. This study was undertaken to determine the prevalence of visual impairment, cataract surgery and awareness of cataract and glaucoma among(More)
PURPOSE To describe the first pediatric cataract surgery case series report from Nepal. SETTING Tilganga Eye Center, Kathmandu, Nepal. METHODS This study comprised a consecutive series of 112 eyes of 85 children having cataract surgery with intraocular lens (IOL) implantation. General anesthesia of ketamine combined with peribulbar block was used in all(More)
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease(More)
BACKGROUND To describe the methodology and baseline data of a population-based study designed to determine the prevalence of glaucoma and to study the risk factors for glaucoma development in a Nepali population. DESIGN Population-based cross-sectional study. PARTICIPANTS Subjects 40 years and above residing in Bhaktapur District. PATIENTS AND METHODS(More)
PURPOSE The purpose of the study was to evaluate the characteristics of central corneal thickness and its association with age, sex, and intraocular pressure in a Nepalese population. PATIENTS AND METHODS The study design was a cross-sectional, population-based survey. Two thousand three hundred thirty patients aged 40 years and older were examined at(More)
PURPOSE To compare the anterior chamber depth (ACD) and axial length of eyes in a population-based sample among normal, occludable angle, and primary angle-closure glaucoma (PACG) groups. METHODS Totally, 3979 subjects from a population-based glaucoma prevalence study underwent complete ocular examination including four mirror gonioscopy. An angle in(More)
OBJECTIVE To determine the prevalence and types of glaucoma in a Nepalese population. DESIGN Cross-sectional, population-based survey. PARTICIPANTS A total of 4800 subjects aged 40 years or older from the Bhaktapur district of Kathmandu valley. METHODS Subjects aged 40 years or older were selected using a cluster sampling procedure and door-to-door(More)
PURPOSE A recent large genome-wide association study (GWAS) identified multiple variants associated with primary angle-closure glaucoma (PACG). The present study investigated the role of these variants in two cohorts with PACG recruited from Australia and Nepal. METHOD Patients with PACG and appropriate controls were recruited from eye clinics in(More)
BACKGROUND To evaluate the visual outcome after cataract surgery in a population of Nepal. DESIGN Population-based cross-sectional study. PARTICIPANTS Forty years and above residing in Bhaktapur district. METHODS Subjects were selected from 30 clusters using cluster sampling procedure. All underwent a detailed examination at the base hospital,(More)