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Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development.
TLDR
This study provides the first direct evidence that the aphakia allele of Pitx3 is a hypomorph and that Pitx 3 is required for the regulation of TH expression in midbrain dopaminergic neurons as well as the generation and/or maintenance of these cells. Expand
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors
TLDR
The data suggest that EpiSC pluripotency encompasses a range of reversible lineage-biased states reflecting the birth of pioneer lineage precursors from a pool of uncommitted Epi SCs similar to the earliest cell fate restriction events taking place in the gastrula stage epiblast. Expand
Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of
TLDR
The estimates indicate that the cumulative activity of the AGM region and the yolk sac is sufficient to provide the day 12 liver with a large number of definitive HSC/RUs, suggesting that the large pool of Definitive HSCs in day 12 foetal liver is formed predominantly by recruiting 'ready-to-use' definitive H SCs from extra-hepatic sources. Expand
Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons
TLDR
The Pitx3 knock‐in mice could be used for purifying primary neurons for molecular studies associated with the midbrain‐specific DA phenotype at a level not previously feasible and provide a useful tool to study DA fate determination from embryo‐ or adult‐derived neural stem cells. Expand
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region
A CD45-negative population of pre-HSCs develops into definitive HSCs in the AGM region of the embryo.
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
TLDR
It is reported here that stage-specific reciprocal dorso–ventral inductive interactions and lateral input from the urogenital ridges are required to drive HSC development in the aorta. Expand
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors
In Fig. 6, NM precursors were wrongly depicted as T(Bra)+Foxa2+ instead of T(Bra)+Sox2+. The corrected figure appears below. The authors apologise to readers for this mistake.
Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver
TLDR
A quantitative approach reveals how the pre-HSC pool undergoes dramatic growth in the aorta-gonad-mesonephros region and, by E11.5, reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver. Expand
Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this
TLDR
It is reported that Runx1 deficiency does not preclude formation of VE-cad+CD45−CD41+ cells, which are phenotypically equivalent to precursors of definitive HSCs but blocks transition to the subsequent CD45+ stage (pre-HSC Type II). Expand
SoxB transcription factors specify neuroectodermal lineage choice in ES cells
TLDR
It is reported that forced expression of Sox1 or Sox2 did not impair propagation of undifferentiated ES cells, but upon release from self-renewal promoted differentiation into neuroectoderm at the expense of mesoderm and endoderm. Expand
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