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Efficient phagocytosis of apoptotic cells is crucial for many cellular processes. One of earliest signals to the phagocyte is the expression of phosphatidylserine (PS) on the outer surface of the apoptotic cell that provides a potent 'eat-me' signal. Recognition of PS occurs either directly, via PS receptor (PS-R), or indirectly via alphavbeta5(3) integrin(More)
Opsonization of apoptotic cells facilitates recognition by phagocytes for the rapid clearance of potentially inflammatory cellular material. The secreted glycoprotein Milk Fat Globule Factor-E8 (MFG-E8) is a member of this family of bridging molecules and is believed to bind phosphatidylserine (PS) on the dying cell, linking it to integrin receptors on the(More)
Telemedicine, among other things, involves storage and transmission of medical images, popularly known as teleradiology. Due to constraints on bandwidth and storage capacity, a medical image may be needed to be compressed before transmission/storage. Among various compression techniques, transform-based techniques that convert an image in spatial domain(More)
This paper presents a method for classification of liver ultrasound images based on texture analysis. The proposed method uses a set of seven texture features having high discriminative power which can be used by radiologists to classify the liver. Feature extraction is carried out using the following texture Based upon the results of Linear Discriminative(More)
It is highly acknowledged in the medical profession that density of breast tissue is a major cause for the growth of breast cancer. Increased breast density was found to be linked with an increased risk of breast cancer growth, as high density makes it difficult for radiologists to see an abnormality which leads to false negative results. Therefore, there(More)
Image compression is a very important issue for several applications in the area of multimedia communications, the objective being reduction of storage and transmission costs. Many efficient coding techniques have been developed for various applications. Amongst them, the Joint Photographic Experts Group (JPEG) has been recommended for compression of(More)
This paper presents a SVM based computer-aided diagnosis (CAD) system for the characterization of clustered microcalcifications in digitized mammograms. First, the region of interest (ROI) in mammogram is enhanced using morphological enhancement (MORPHEN) method. Second, pixels in potential microcalcification regions are segmented out by using edge(More)
Integrin receptors are heterodimeric transmembrane receptors with critical functions in cell adhesion and migration, cell cycle progression, differentiation, apoptosis, and phagocytosis of apoptotic cells. Integrins are activated by intracellular signaling that alter the binding affinity for extracellular ligands, so-called inside to outside signaling. A(More)
It has been 50 years since the initial descriptions of what are now known as plasmacytoid dendritic cells (pDC) and type I IFN. pDC, which are infrequent cells found in the peripheral blood and lymphoid organs, are the most potent producers of type I and type III IFNs in the body. pDC produce IFN-alpha in response to both DNA and RNA enveloped viruses by(More)