Sukbin Lim

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Many neuronal systems exhibit slow random alternations and sudden switches in activity states. Models with noisy relaxation dynamics (oscillatory, excitable or bistable) account for these temporal, slow wave, patterns and the fluctuations within states. The noise-induced transitions in a relaxation dynamics are analogous to escape by a particle in a slowly(More)
Persistent neural activity in the absence of a stimulus has been identified as a neural correlate of working memory, but how such activity is maintained by neocortical circuits remains unknown. We used a computational approach to show that the inhibitory and excitatory microcircuitry of neocortical memory-storing regions is sufficient to implement a(More)
To my family iii Acknowledgments First, I would like to express my heartfelt thanks to my advisor Prof. Olof Widlund. I appreciate all his contributions of time, ideas, and unlimited support. His guidance helped me completing my degree. Whenever I got stuck, he always suggested the right direction to me. I have been fortunate to have worked with him. I am(More)
In short-term memory networks, transient stimuli are represented by patterns of neural activity that persist long after stimulus offset. Here, we compare the performance of two prominent classes of memory networks, feedback-based attractor networks and feedforward networks, in conveying information about the amplitude of a briefly presented stimulus in the(More)
A hallmark of working memory is the ability to maintain graded representations of both the spatial location and amplitude of a memorized stimulus. Previous work has identified a neural correlate of spatial working memory in the persistent maintenance of spatially specific patterns of neural activity. How such activity is maintained by neocortical circuits(More)
Information about external stimuli is thought to be stored in cortical circuits through experience-dependent modifications of synaptic connectivity. These modifications of network connectivity should lead to changes in neuronal activity as a particular stimulus is repeatedly encountered. Here we ask what plasticity rules are consistent with the differences(More)
Persistent patterns of neural activity that last long after the offset of a stimulus are thought to be the neural substrate for short-term memory. Because the observed decay of persistent activity in memory circuits is much slower than the typical decay time constants associated with synaptic or intrinsic neuronal dynamics, it has been suggested that(More)
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