Suk Chul Shin

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This study evaluated the effects of low dose radiation on spermatogenic cells using the morphological characteristics of sperm in the caudal epididymis of ICR mice. In this study, six abnormal sperm shapes (amorphous heads, blunt hooks, excessive hooks, two heads and tails, folded tails and short tails) were observed at eight days after gamma-irradiation(More)
To evaluate the effect of low-dose-rate radiation on cancer incidence, we housed AKR/J mice in a long-term low-dose-rate irradiation facility ((137)Cs, 0.07 cGy/h). We compared the thymic lymphoma incidence and life span with those of mice irradiated at a high dose rate ((137)Cs, 0.8 Gy/min, total dose of 4.5 Gy) and nonirradiated mice. The average life(More)
AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes(More)
While a high-dose of ionizing radiation is generally harmful and causes damage to living organisms, a low-dose of radiation has been shown to be beneficial in a variety of animal models. To understand the basis for the effect of low-dose radiation in vivo, we examined the cellular and immunological changes evoked in mice exposed to low-dose radiation at(More)
The possible beneficial effects of chronic low-dose irradiation (LDR) and its mechanism of action in a variety of pathophysiological processes such as cancer are a subject of intense investigation. While animal studies involving long-term exposure to LDR have yielded encouraging results, the influence of LDR at the cellular level has been less well defined.(More)
We previously determined that AKR/J mice housed in a low-dose-rate (LDR) ((137)Cs, 0.7 mGy/h, 2.1 Gy) γ-irradiation facility developed less spontaneous thymic lymphoma and survived longer than those receiving sham or high-dose-rate (HDR) ((137)Cs, 0.8 Gy/min, 4.5 Gy) radiation. Interestingly, histopathological analysis showed a mild lymphomagenesis in the(More)
We have investigated radiation-sensitive expressed genes (EGs), their signal pathways, and the effects of ionizing radiation in the thymus of ICR and AKR/J mice. Whole-body and relative thymus weights were taken and microarray analyses were done on the thymuses of high-dose-rate (HDR, (137) Cs, 0.8 Gy/min, a single dose of 4.5 Gy) and low-dose-rate (LDR,(More)
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