Sujith Samarasinghe

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T he childhood bone marrow failure disorders are a heterogeneous group of diseases of which the common-est ones are acquired severe aplastic anemia (SAA) and myelodysplastic syndromes. SAA is characterized by the presence of pancytopenia with a hypocellular marrow in the absence of malignant infiltration or fibrosis. Myelodysplastic syndromes are(More)
To determine whether in vivo T-cell depletion, which lowers GVHD, abrogates the antileukemic benefits of myeloablative total body irradiation-based conditioning and unrelated donor transplantation, in the present study, we analyzed 715 children with acute lymphoblastic leukemia. Patients were grouped for analysis according to whether conditioning included(More)
Letters to the Editor 151 Fig. 1. Blood film demonstrating chronic myeloid leukemia in lymphoid blast transformation. in beta-thalassemia patients: a single-center experience and a concise review of the literature. Chronic myelogenous leukemia in sickle cell/beta 0-thalassemia. of lymphoma with bone marrow involvement in a boy with beta+ thalassaemia major.(More)
Bone marrow failure syndromes (BMFS) are a group of disorders with complex pathophysiology characterized by a common phenotype of peripheral cytopenia and/or hypoplastic bone marrow. Understanding genetic factors contributing to the pathophysiology of BMFS has enabled the identification of causative genes and development of diagnostic tests. To date more(More)
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