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Ontogenetic De Novo Copy Number Variations (CNVs) as a Source of Genetic Individuality: Studies on Two Families with MZD Twins for Schizophrenia
Genome-wide alterations in two nuclear families each with a pair of monozygotic twins discordant for schizophrenia evaluated by the Affymetrix 6.0 human SNP array are reported to argue for enduring genome-wide changes during cellular transmission. Expand
Genetic determinants of immune-response to a polysaccharide vaccine for typhoid
Differences in immunological response among vaccine recipients are determined both by their genetic differences and environmental factors. Knowledge of genetic determinants of immunological responseExpand
Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer
The roles of cyclo-oxygenase (COX)-2 induced miR526b and miR655 in tumour-associated angiogenesis and lymphangiogenesis are examined and EP4 is considered as a potential therapeutic target to abrogate miRNA-induced angiogenic and lymphangaogenesis in breast cancer. Expand
Genetic variation and haplotype structures of innate immunity genes in eastern India.
The SNP density in innate immunity genes observed in this study (>3SNPskb(-1)) exceeds the highest density observed for any autosomal chromosome in the human genome. Expand
miR526b and miR655 Induce Oxidative Stress in Breast Cancer
The dynamic functions of miR526b/miR655 in oxidative stress induction in breast cancer are established, and treatment with miRNA-conditioned media upregulates TXNRD1 in both MCF7 and HUVECs, indicating that oxidative stress also induces miRNA overexpression. Expand
Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer
Hypoxia enhances miRNA functions following the COX-2/EP4/PI3K/Akt pathways and this pathway can serve as a therapeutic target to abrogate hypoxia and miRNA induced functions in breast cancer. Expand
Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish
The novel roles of PGE2 in promoting embryonic vascular maturation and angiogenesis in zebrafish are shown, which causes inflammation and cancer and its blockage results in serious physiological consequences. Expand
Genomic correlates of variability in immune response to an oral cholera vaccine
Cholera is endemic to many countries. Recent major outbreaks of cholera have prompted World Health Organization to recommend oral cholera vaccination as a public-health strategy. Variation inExpand
Comprehensive Assessment of CNV Calling Algorithms: A Family Based Study Involving Monozygotic Twins Discordant for Schizophrenia
Microarray data generation using the Affymetrix Genome Wide Human SNP Array and selection of packages for Microarray data analysis. Expand
A novel deletion cluster at 13q14.2-q21.33 in an 80-year man with late onset leukemia: Clinical and molecular findings
The study highlights the role of ongoing de novo changes at susceptible sites, such as repeat rich regions, in the human genome and argues for the involvement of genes/deletions in the 13q(14.2-21.33) region in the development of CCL. Expand