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Introduction Machine learning (Hastie et al. 2001) is a subset of artificial intelligence and deals with techniques to allow computers to learn. Bioinformatics is the application of information technology to the area of molecular biology. For both disciplines there are already many books introducing the basic concepts and there are some books presenting(More)
Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation pathways. The present study investigates the interplay between crucial myogenic, adipogenic, and Wnt-related genes orchestrating aged myogenic progenitor differentiation (AMPD) using clonal gene expression profiling in conjunction with Bayesian structure(More)
Massively Parallel Signature Sequencing (MPSS) is a high-throughput counting-based technology available for gene expression profiling. It produces output that is similar to Serial Analysis of Gene Expression (SAGE) and is ideal for building complex relational databases for gene expression. Our goal is to compare the in vivo global gene expression profiles(More)
We are not even halfway through the second decade of the 21st century and there is already ample evidence that it is going to be the century of biotechnology, leading to unprecedented breakthroughs in the medical sciences and revolutionizing everything from drug discovery to healthcare delivery. The rapid advancement in high-performance computing that took(More)
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