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Dystrophin links the transmembrane dystrophin-glycoprotein complex to the actin cytoskeleton. We have shown that dystrophin-glycoprotein complex subunits are markers for airway smooth muscle phenotype maturation and together with caveolin-1, play an important role in calcium homeostasis. We tested if dystrophin affects phenotype maturation, tracheal(More)
House dust mite (HDM) challenge is commonly used in murine models of allergic asthma for preclinical pathophysiological studies. However, few studies define objective readouts or biomarkers in this model. In this study we characterized immune responses and defined molecular markers that are specifically altered after HDM challenge. In this murine model, we(More)
Objective/purpose Evidence is emerging that human exposure to environmentally ubiquitous perfluorooctanoic acid (PFOA), used commonly for its household stain repellency characteristics , is associated with immunologic changes. Data from adults near an industrial PFOA disposal site demonstrated a strong negative correlation between blood PFOA concentrations(More)
Plants of medicinal importance though are quite well known among the Ayurvedic practitioners since years, yet many of them have not been standardized, validated and documented completely. Among such medicinally valuable plants, Salacia holds a place as an effective antidiabetic herb and many species of this plant are in use as anti-diabetics. The present(More)
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