Suien Tang

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The involvement of cholinergic transmission in heroin self-administration and the reinstatement of heroin-seeking was examined in rats trained to nose-poke for i.v. heroin. Systemic treatment with physostigmine, an inhibitor of acetylcholinesterase, modestly reduced the acquisition and rate of heroin self-administration, and this suppression of heroin(More)
RATIONALE A high incidence of relapse can be triggered by exposure to conditioned cues previously associated with heroin. Extended access to drug and withdrawal are thought to affect the motivation for drug seeking. OBJECTIVES The present study evaluated how different periods of training to self-administer heroin and different periods of withdrawal(More)
Nicotine was administered to adult female rats in drinking water starting 6 weeks before mating and continuing throughout pregnancy. The litters were cross-fostered to control dams at birth. Prenatal nicotine treatment reduced both the number of male rats born and the male birth weight. Female offspring were not significantly affected. Rearing activity was(More)
Rats were given dilute nicotine solutions as their only source of drinking water while control rats received distilled water. Two months after the start of treatment the rats were mated. At birth litters born to nicotine treated rats were either left with the dams until weaning (nicotine group) or cross-fostered to control dams (cross-fostered nicotine(More)
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