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This correspondence introduces a multidrug cancer chemotherapy model to simulate the possible response of the tumor cells under drug administration. We formulate the model as an optimal control problem. The algorithm in this correspondence optimizes the multidrug cancer chemotherapy schedule. The objective is to minimize the tumor size under a set of(More)
This paper proposes a new memetic algorithm (MA) to solve the Multi-drug chemotherapy optimization problem. The new MA combines GA with a local search algorithm called Iterative Dynamic Programming (IDP). A multi-drug chemotherapy model is introduced to simulate the possible response of the tumor cells under drugs administration. Optimization of the(More)
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