• Publications
  • Influence
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identifyExpand
  • 66
  • 5
  • PDF
BRCA1 and MicroRNAs: Emerging networks and potential therapeutic targets
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies have established BRCA1’s role in diverse cellular and biochemicalExpand
  • 34
  • 2
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis.Expand
  • 18
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 inExpand
  • 14
  • PDF
Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay.
We describe here a comprehensive and reliable assay to test the functional significance of variants of unknown clinical significance (VUS) identified in the human breast cancer susceptibility gene,Expand
  • 6
Epigenetic control of an oncogenic microRNA, miR-155, by BRCA1
Since its identification in 1994, BRCA1 (Breast Cancer 1) has been established as a familial early onset breast and ovarian cancer susceptibility gene [1]. The protein encoded by this gene isExpand
  • 24
  • PDF
A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells
Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compoundsExpand
  • 8
BRCA 1 and MicroRNAs : Emerging Networks and Potential Therapeutic Targets
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies have established BRCA1’s role in diverse cellular and biochemicalExpand
  • 4
  • PDF
Repair and Its Clinical Implications Degradation of BRCA 2 in Alkyltransferase-Mediated DNA
Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 inExpand