Suhail Ayesh

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BACKGROUND Mutations and epigenetic aberrant signaling of growth factors pathways contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its expression is shut off in most tissues postnatally,(More)
We report the first Palestinian child manifesting with 3-methylglutaconic aciduria psychomotor delay, muscle hypotonia, sensori-neural deafness, and Leigh-like lesions on brain magnetic resonance imaging (MRI), a clinical phenotype that is characteristic of MEGDEL syndrome. MEGDEL syndrome was recently found to be caused by mutations in SERAC1, encoding a(More)
The first and second authors contributed equally to this work. Summary H19 is a maternally expressed oncofetal gene, which is expressed at substantial levels in embryonic tissues and various human tumor types, but marginally or not expressed in the corresponding tissue of the adult. Dramatic increase in H19 mRNA was found in hepatocytes following the(More)
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