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Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.
Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. In order to gain insight into the… Expand
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.
Endoplasmic reticulum (ER) stress-mediated apoptosis may play a crucial role in loss of pancreatic beta cell mass, contributing to the development of diabetes. Here we show that induction of 4E-BP1,… Expand
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Wolfram syndrome, an autosomal recessive disorder associated with diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene encoding an endoplasmic reticulum (ER) membrane protein.… Expand
WFS1 protein modulates the free Ca2+ concentration in the endoplasmic reticulum
The WFS1 gene, encoding an endoplasmic reticulum (ER) membrane glycoprotein, is mutated in Wolfram syndrome characterized by diabetes mellitus and optic atrophy. Herein, Ca2+ dynamics were examined… Expand
Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses
Background— The processes of arteriosclerosis, including atherosclerosis and vascular remodeling, are affected by interactions among numerous biological pathways such as responses to inflammation,… Expand
Direct Correlation Between Ischemic Injury and Extracellular Glycine Concentration in Mice With Genetically Altered Activities of the Glycine Cleavage Multienzyme System
Background and Purpose— Ischemia elicits the rapid release of various amino acid neurotransmitters. A glutamate surge activates N-methyl-d-aspartate (NMDA) glutamate receptors, triggering deleterious… Expand
DBS: a powerful tool for TCP performance evaluations
Network performance measurement tools, mainly used for TCP performance evaluations, have serious problems that their applications are limited to single point-to-point configuration and only the mean… Expand
Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors.
- Rui Takahashi, H. Ishihara, +5 authors Y. Oka
- Medicine, Biology
- Journal of molecular endocrinology
Gene transfer with adenovirus vectors has been used extensively for pancreatic islet research. However, infection efficiency varies among reports. We reevaluated the infection efficiency, defined… Expand
The JNK pathway modulates expression and phosphorylation of 4E‐BP1 in MIN6 pancreatic β‐cells under oxidative stress conditions
- Ryu Tominaga, Suguru Yamaguchi, +6 authors H. Ishihara
- Biology, Medicine
- Cell biochemistry and function
- 1 July 2010
Stress‐mediated apoptosis may play a crucial role in loss of pancreatic β‐cell mass, contributing to the development of diabetes. We have recently identified that translational control involving the… Expand
Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2…
- Y. Otsuka, Suguru Yamaguchi, Asami Furukawa, Minami Kosuda, Mitsuhiro Nakazaki, H. Ishihara
- Endocrine journal
This study aimed to explore the effects of the dipeptidyl peptidase-4 inhibitor sitagliptin and the biguanide metformin on the secretion of insulin and glucagon, as well as incretin levels, in… Expand