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  • Sundarapandian Thangapandian, Shalini John, Sugunadevi Sakkiah, Keun Woo Lee
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2010 (First Publication: 1 October 2010)
  • Over expression of histone deacetylases (HDACs) leads to the suppression of various gene expressions including cancer suppressor gene. Thus, novel inhibitors of these enzymes can be a valid method toContinue Reading
  • Mahreen Arooj, Sugunadevi Sakkiah, Songmi Kim, Venkatesh Arulalapperumal, Keun Woo Lee
  • Chemistry, Medicine
  • PloS one
  • 2013 (First Publication: 26 April 2013)
  • Inhibition of chymase is likely to divulge therapeutic ways for the treatment of cardiovascular diseases, and fibrotic disorders. To find novel and potent chymase inhibitors and to provide a new ideaContinue Reading
  • Sugunadevi Sakkiah, Sundarapandian Thangapandian, Shalini John, Yong Jung Kwon, Keun Woo Lee
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2010 (First Publication: 1 June 2010)
  • Chemical features based 3D pharmacophore models were developed for HSP90 based on the known inhibitors using Discovery Studio V2.1. An optimal pharmacophore model was brought forth and validatedContinue Reading
  • Shalini John, Sundarapandian Thangapandian, Sugunadevi Sakkiah, Keun Woo Lee
  • Biology, Medicine, Computer Science
  • BMC Bioinformatics
  • 2011 (First Publication: 15 February 2011)
  • BackgroundBeta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane protein belongs to the aspartyl protease class of catabolic enzymes. This enzyme involved in the processingContinue Reading
  • Mahreen Arooj, Sugunadevi Sakkiah, Guang ping Cao, Keun Woo Lee
  • Chemistry, Medicine
  • PloS one
  • 2013 (First Publication: 5 April 2013)
  • Due to the diligence of inherent redundancy and robustness in many biological networks and pathways, multitarget inhibitors present a new prospect in the pharmaceutical industry for treatment ofContinue Reading
  • Shalini John, Sundarapandian Thangapandian, Sugunadevi Sakkiah, Keun Woo Lee
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2010 (First Publication: 1 September 2010)
  • Indoleamine 2,3-dioxygenase, a heme-containing enzyme, is emerging as a vital target for the treatment of cancer, chronic viral infections, and other diseases. The aim of this study is to identifyContinue Reading