Sufang Tian

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A common motif found in invertebrate serine proteases involved in immunity and development is the clip domain, proposed to regulate catalytic activity or protein-protein interactions within proteolytic cascades. Snake functions in a cascade that patterns the Drosophila embryo, and provides an accessible model for exploring the structural requirements for(More)
During Drosophila embryogenesis, establishment of ventral and lateral cell fates requires spatial regulation of an extracellular serine protease cascade composed of Nudel, Gastrulation Defective (GD), Snake, and Easter. Pipe, a sulfotransferase expressed ventrally during oogenesis, sulfates secreted targets that somehow confer positive spatial input to this(More)
In this study, we used the “cell-SELEX” strategy to generate four new aptamers with high binding affinity for Huh7.5.1. and HepG2 cells, as indicated by Kd values in the low nanomolar range, as well as high specificity compared to L-02 normal human liver cells. Moreover, the aptamers could distinguish human liver tumour tissues from normal tissues.(More)
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