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A randomised controlled trial with a factorial design was done to examine the effects of dietary intervention in the secondary prevention of myocardial infarction (MI). 2033 men who had recovered from MI were allocated to receive or not to receive advice on each of three dietary factors: a reduction in fat intake and an increase in the ratio of(More)
OBJECTIVE We examined whether glucose transporter 1 (GLUT1) deficiency causes common idiopathic generalized epilepsies (IGEs). METHODS The IGEs are common, heritable epilepsies that usually follow complex inheritance; currently little is known about their genetic architecture. Previously considered rare, GLUT1 deficiency, due to mutations in SLC2A1, leads(More)
A two-centre trial has been carried out on 224 patients with chronic plaque psoriasis randomly allocated to treatment with a standard dithranol regimen of 8-methoxypsoralen and long-wave ultraviolet light (P.U.V.A.). Lesions in 91% of the 113 in the P.U.V.A. group cleared satisfactorily compared with 82% of 111 in the dithranol group, but clearing took(More)
Obesity has emerged as a major co-morbidity in patients with psoriasis. In a case control study we found that patients with psoriasis had significantly higher body mass indices (BMI) compared to controls (p = 0.004). Increased adiposity and weight gain were strong risk factors for the development of psoriasis in the Nurses Health study 1. Multivariate(More)
Cell suspension from the spleen of rabbits immunised with monkey brain gave rise to epileptic discharges in the monkey when injected intracortically, except in the case of one injection from a rabbit not recently given a booster treatment. In contrast, cell suspensions from the spleen of unimmunised rabbits, or of a rabbit immunised with a non-brain(More)
Photochemotherapy for psoriasis combining orally administered methoxsalen and long-wave ultraviolet (UVA) light was used in 186 patients with severe psoriasis. Several different phototherapy units with various numbers of GE high-output black lights were used. Excellent (90% to 100% clear) and good (80% to 90% clear) results were obtained in 77% of the(More)