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BACKGROUND There is scant evidence on the effect that chronic kidney disease (CKD) confers on clinically meaningful outcomes among patients with heart failure with preserved left ventricular ejection fraction (HF-PEF). METHODS AND RESULTS We identified a community-based cohort of patients with HF. Electronic medical record data were used to divide into(More)
BACKGROUND A clear need exists for a more systematic understanding of the epidemiology, diagnosis, and management of cardiovascular diseases. More robust data are also needed on how well clinical trials are translated into contemporary community practice and the associated resource use, costs, and outcomes. METHODS AND RESULTS The National Heart, Lung,(More)
BACKGROUND Atrial fibrillation (AF) and heart failure (HF) are 2 of the most common cardiovascular conditions nationally and AF frequently complicates HF. We examined how AF has impacts on adverse outcomes in HF-PEF versus HF-REF within a large, contemporary cohort. METHODS AND RESULTS We identified all adults diagnosed with HF-PEF or HF-REF based on(More)
Karen Tallman, PhD, is a senior research analyst for the Care Experience Council. E-mail: karen.tallman@kp.org. Tom Janisse, MD, is the Editor-in-Chief of The Permanente Journal and publisher of The Permanente Press. E-mail: tom.janisse@kp.org. Richard M Frankel, PhD, is Professor of Medicine and Geriatrics at Indiana University School of Medicine. He is(More)
BACKGROUND Although heart failure (HF) is a syndrome with important differences in response to therapy by left ventricular ejection fraction (LVEF), existing risk stratification models typically group all HF patients together. The relative importance of common predictor variables for important clinical outcomes across strata of LVEF is relatively unknown.(More)
BACKGROUND The accuracy of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Risk Equation for atherosclerotic cardiovascular disease (ASCVD) events in contemporary and ethnically diverse populations is not well understood. OBJECTIVES The goal of this study was to evaluate the accuracy of the 2013 ACC/AHA Pooled(More)
BACKGROUND Ambulatory electrocardiographic (ECG) monitoring is the standard to screen for high-risk arrhythmias. We evaluated the clinical utility of a novel, leadless electrode, single-patient-use ECG monitor that stores up to 14 days of a continuous recording to measure the burden and timing of potentially high-risk arrhythmias. METHODS We examined data(More)
Despite repeated calls for greater patient autonomy, shared decision making, and exploration of patient preferences, relatively little is known about how patients actually experience care as a face-to-face interactional process. A selected review of the literature in this area suggests that important asymmetries exist. Key among them is the tendency to(More)
BACKGROUND Clinical guidelines recommend digoxin for patients with symptomatic systolic heart failure (HF) receiving optimal medical therapy, but this recommendation is based on limited, older trial data. We evaluated the effectiveness and safety of digoxin in a contemporary cohort of patients with incident systolic HF. METHODS AND RESULTS We identified(More)