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Hepatitis C virus (HCV) is a blood-borne pathogen and a major cause of liver disease worldwide. Gene expression profiling was used to characterize the transcriptional response to HCV H77c infection. Evidence is presented for activation of innate antiviral signaling pathways as well as induction of lipid metabolism genes, which may contribute to oxidative(More)
altered gene transcription , through which previous exposure to cocaine can influence the subsequent subjective qualities of the drug. Repeated exposure to cocaine causes an up-regulation of dynorphin expression through stimulation of dopamine D1-type receptors and the cAMP pathway (2, 7, 15). Upon subsequent exposure to cocaine, augmented release of(More)
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