Learn More
Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been linked with the development and maintenance of nociception. We studied the role of the inducible isoform,(More)
The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been implicated in chronic pain states in rat and man. A number of COX-2(More)
Several studies have implicated a potential role for histamine H(3) receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the(More)
We have investigated the role of the inducible isoform (iNOS) in models of inflammatory and neuropathic hypersensitivity using immunohistochemistry, chemiluminescence and the selective iNOS inhibitor(More)