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STUDY OBJECTIVES To examine electrocardiographic findings after short- and long-term tiotropium therapy in patients with chronic obstructive pulmonary disease (COPD), and to establish previously reported symptomatic efficacy. DESIGN Randomized, double-blind, placebo-controlled, parallel-group study. SETTING Twelve outpatient investigational centers in(More)
OBJECTIVEdTo evaluate the efficacy and long-term safety of linagliptin added to basal insulins in type 2 diabetes inadequately controlled on basal insulin with or without oral agents. RESEARCH DESIGN AND METHODSdA total of 1,261 patients (HbA 1c $7.0% [53 mmol/mol] to #10.0% [86 mmol/mol]) on basal insulin alone or combined with metformin and/ or(More)
BACKGROUND Addition of a sulphonylurea to metformin improves glycaemic control in type 2 diabetes, but is associated with hypoglycaemia and weight gain. We aimed to compare a dipeptidyl peptidase-4 inhibitor (linagliptin) against a commonly used sulphonylurea (glimepiride). METHODS In this 2-year, parallel-group, non-inferiority double-blind trial,(More)
OBJECTIVE To evaluate the efficacy and long-term safety of linagliptin added to basal insulins in type 2 diabetes inadequately controlled on basal insulin with or without oral agents. RESEARCH DESIGN AND METHODS A total of 1,261 patients (HbA1c ≥7.0% [53 mmol/mol] to ≤10.0% [86 mmol/mol]) on basal insulin alone or combined with metformin and/or(More)
Solid tumor survives by the generation of micro-vessels around it. This phenomenon is known as angiogenesis. Angiogenesis is governed by two factors, namely Tumor Angiogenic Factor (TAF) secreted by the tumor cells and tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby(More)
OBJECTIVE To evaluate the efficacy and long-term safety of linagliptin added to basal insulin in Asian patients with type 2 diabetes mellitus (T2DM) inadequately controlled by basal insulin with/without oral agents. RESEARCH DESIGN AND METHODS This was a post hoc analysis of Asian patients from a global ≥52 week study in which patients on basal insulin(More)
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