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The recent emergence of lab-on-a-chip (LoC) technology has led to a paradigm shift in many healthcare-related application areas, e.g., point-of-care clinical diagnostics, high-throughput sequencing, and proteomics. A promising category of LoCs is digital microfluidic (DMF)-based biochips, in which nanoliter-volume fluid droplets are manipulated on a 2-D(More)
In many biochemical protocols, solution preparation is a preprocessing step for mixing two or more fluids in a given ratio. Dilution of a biochemical sample/reagent is the special case of mixing or solution preparation where only two different type of fluids, one of which is a buffer solution, are mixed at a certain ratio corresponding to the desired(More)
A key challenge in design automation of digital microfluidic biochips is to carry out on-chip dilution/mixing of biochemical samples/reagents for achieving a desired concentration factor (CF). In a bioassay, reducing the waste is crucial because the waste droplet handling is cumbersome and the number of waste reservoirs on-chip needs to be minimized to use(More)
The recent proliferation of digital microfluidic (DMF) biochips has enabled rapid on-chip implementation of many biochemical laboratory assays or protocols. Sample preprocessing, which includes dilution and mixing of reagents, plays an important role in the preparation of assays. The automation of sample preparation on a digital microfluidic platform often(More)
Digital microfluidic biochips are recently being developed for on-chip implementation of biochemical laboratory assays. Existing mixing algorithms determine the mixing tree or mixing graph from a given target ratio of several biochemical fluids for on-chip mixture preparation. We present an algorithm to determine a reduced mixing tree by sharing the common(More)
Recent proliferation of sensor networks in diverse applications has made the low-power wireless sensor network an important design issue. Structural health monitoring is one of the important applications of the wireless sensor network. A robust wireless structural monitoring strategy requires appropriate choice of the wireless network topology as well as(More)
On-chip mixing of several biochemical fluids with a specified ratio of concentration factors is a challenging problem in automating biochemical laboratory protocols on a digital microfluidic biochip. The performance of a mixing algorithm depends on resource allocation, e.g., the placement of mixer modules, storage units, boundary reservoirs or dispensers on(More)
Digital microfluidic (DMF) biochips are recently being advocated for fast on-chip implementation of biochemical laboratory assays or protocols, and several algorithms for diluting and mixing of reagents have been reported. However, all methods for such automatic sample preparation suffer from a drawback that they assume the availability of input fluids in(More)