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Binding of peptides to specific Major Histo-compatibility Complex (MHC) molecule is important for understanding immunity and has applications to vaccine discovery and design of immunotherapy. Artificial neural networks (ANN) are widely used by predictions tools to classify the peptides as binders or non-binders (BNB). However, the number of known binders to(More)
Fundamental step of an adaptive immune response to pathogen or vaccine is the binding of short peptides (also called epitopes) to major histocompatibility complex (MHC) molecules. The various prediction algorithms are being used to capture the MHC peptide binding preference, allowing the rapid scan of entire pathogen proteomes for peptide likely to bind(More)
Peptide based vaccines play an important role in activating the immune response. The small peptides derived from target proteins (epitopes) of an invading pathogen, bacteria, or virus bind with the MHC molecules are recognized by CD4+ T cells or CD8+ T cells. MHC class I molecules are recognized by CD4+ T cells and MHC class – II molecules are recognized by(More)
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