Sudhir Sastry

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A specific mutation (A53T) in the encoding region for alpha-synuclein has been identified in a large multigenerational family with an autosomal dominant parkinsonism known as the Contursi kindred. In this study, we used a monoclonal antibody directed against alpha-synuclein in order to identify novel proteins in the brain of an affected member of this(More)
Alpha-synuclein has recently been shown to be a major constituent of Lewy bodies in Parkinson's disease (PD). This observation led us to investigate the possibility that its detection in the cerebrospinal fluid (CSF) could be used as a marker for Lewy bodies in the central nervous system. In this study we determined the pattern of expression of(More)
Based on surveillance data since 1999, it is estimated that each year pathogenic bacteria cause 9.4 million foodborne illnesses, 55,961 hospitalizations, and 1,351 deaths in the United States (1). The financial impact of foodborne illness in the United States is estimated— based on medical costs, productivity losses (pain, suffering , and functional(More)
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