Sudhir Perincheri

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The insulin-like growth factor (IGF) axis is fundamentally important in cell growth, development and cancer. We used genomic technologies to better characterize the activity of the IGF axis in human breast cancer and to identify predictors of response to IGF targeted therapies. Analysis of the gene expression patterns and pathway analysis in 204 clinically(More)
Breast cancer is the most common malignancy and a leading cause of cancer related deaths in women. In recent years, gene expression profiling has proved useful in delineating molecular subtypes of breast cancer and in the development of prognostic signatures. We are developing an analytical pipeline to characterize the transcriptional regulators of these(More)
Activating mutation of KRAS plays a significant role in the pathogenesis of common human malignancies and molecular testing of KRAS mutation has emerged as an essential biomarker in the current practice of clinical oncology. The presence of KRAS mutation is generally associated with clinical aggressiveness of the cancer and reduced survival of the patient.(More)
Understanding the interaction and crosstalk between pathways is important for understanding the function of both physiological and pathological biological systems. We have taken a computational approach to explore interactions among modules within biological networks by comparing and contrasting various topological measures which may be useful in the(More)
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