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Development of antibacterial conjugates using sulfamethoxazole with monocyclic terpenes: A systematic medicinal chemistry based computational approach
TLDR
We develop 6 conjugate agents of the moribund antibiotic sulfamethoxazole (SMZ) joined to 6 individual monoterpenes, followed by protocols of medicinal chemistry as potent antibacterials, against multidrug resistant (MDR) human pathogenic bacteria. Expand
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Antibacterial, antifungal and antimycobacterial compounds from cyanobacteria.
Infections from multidrug resistant (MDR) pathogenic bacteria, fungi and Mycobacterium tuberculosis remain progressively intractable. The search of effective antimicrobials from other possibleExpand
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Antimicrobial, analgesic, antioxidant and in silico study of synthesized salicylic acid congeners and their structural interpretation
Abstract A series of azosalicylic acid analogs were newly synthesized by coupling various aryl and heteroarylamine functionalities with salicylic acid nucleus. All the synthesized compounds wereExpand
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Antibacterial activity, computational analysis and host toxicity study of thymol-sulfonamide conjugates.
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus faecalis (VRE) are notorious pathogenic multidrug resistant (MDR) bacteria in both hospital and communityExpand
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Molecular docking and simulation study for synthesis of alternative dapsone derivative as a newer antileprosy drug in multidrug therapy
Leprosy (causative, Mycobacterium leprae) continues to be the persisting public health problem with stable incidence rates, owing to the emergence of dapsone resistance that being the principal drugExpand
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Synthesis of novel thymol derivatives against MRSA and ESBL producing pathogenic bacteria
Abstract Twelve substituted aryl-azo-thymol derivatives (4a to 4 l) were synthesized and characterized by several spectral techniques such as, FTIR, UV-vis, proton NMR, Mass spectrometry andExpand
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Study of antimicrobial, analgesic wound healing and antioxidant activities of some newly synthesized oxychinolin derivatives and their characterization
Abstract A series of aryl and heteroaryl substituted oxychinolin derivatives have been synthesized and spectral characterizations have been conducted with different modern analytical techniques. TheExpand
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Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae
Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-goingExpand
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Norharmane as a potential chemical entity for development of anticancer drugs.
Cancer is a leading cause of death generally, and to overcome this problem the introduction of a new drug developing is a continuous endeavour. An alkaloid, norharmane and its derivatives, which haveExpand
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Nornostocine congeners as potential anticancer drugs: An overview
The naturally occurring phyco‐constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with aExpand
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