Sudhir Agrawal

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– Mobile ad hoc networks (MANETs) are a set of mobile nodes which are self-configuring and connected by wireless links automatically as per the defined routing protocol. The absence of a central management agency or a fixed infrastructure is a key feature of MANETs. These nodes communicate with each other by interchange of packets, which for those nodes not(More)
  • Subhrajit Saha, Payel Bhanja, Laibin Liu, Alan A. Alfieri, Dong Yu, Ekambar R. Kandimalla +2 others
  • 2012
PURPOSE Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis. Intestinal macrophages could recognize invading bacterial DNA via TLR9 receptors and transmit regenerative signals to the neighboring crypt.(More)
Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif act as antagonists of Toll-like receptor (TLR)7 and TLR9. In the present study, we designed and synthesized oligonucleotide-based antagonists of TLR7, 8 and 9 containing a 7-deaza-dG or arabino-G modification in the immune-stimulatory motif and 2'-O-methylribonucleotides(More)
PURPOSE Recent studies have shown that a new generation of synthetic agonist of Toll-like receptor (TLR) 9 consisting a 3'-3'-attached structure and a dCp7-deaza-dG dinucultodie shows more potent immunostimulatory effects in both mouse and human than conventional CpG oligonucleotides. Radiation therapy (RT) provides a source of tumor antigens that are(More)
Location management being a major part of cellular network provides mobility to mobile subscribers. The current location information is required to route the call correctly to the recipient irrespective of its current location. The current HLR/VLR architecture for location management in standards like IS-41 & GSM suffers from call setup delay due to network(More)
  • Mallikarjuna Reddy Putta, FuGang Zhu, Yukui Li, Lakshmi Bhagat, YanPing Cong, Ekambar R. Kandimalla +1 other
  • 2006
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs activate Toll-Like Receptor 9 (TLR9). Our previous studies have shown the role of hydrogen-bond donor and acceptor groups of cytosine and guanine in the CpG motif and identified synthetic immunostimulatory motifs. In the present study to elucidate the significance of N3-position of cytosine(More)
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