Sudhakar Chelikani

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The purpose of this study was to determine if exercise alters wrist joint laxity, as measured by the mechanical behavior of the scaphoid bone. The load-displacement behavior of the scaphoid was studied in the palmar-dorsal direction in both wrists of 7 healthy volunteers (n = 14) before and after 2 exercise protocols (grip and push-up). When compared to the(More)
External beam radiotherapy (EBRT) has become the preferred options for nonsurgical treatment of prostate cancer and cervix cancer. In order to deliver higher doses to cancerous regions within these pelvic structures (i.e. prostate or cervix) while maintaining or lowering the doses to surrounding non-cancerous regions, it is critical to account for setup(More)
—Component-based normalization is an important technique for PET scanners with a high number of lines of response (LOR), e.g., 4 5 10 9 for the HRRT. It reduces the problem of measuring the sensitivity of each LOR to that of estimating the individual crystal efficiencies (), e.g., 119808 for the HRRT. We propose a component-based method to compute for the(More)
External beam radiation therapy (EBRT) for the treatment of cancer enables accurate placement of radiation dose on the cancerous region. However, the deformation of soft tissue during the course of treatment, such as in cervical cancer, presents significant challenges for the delineation of the target volume and other structures of interest. Furthermore,(More)
A constrained non-rigid registration (CNRR) algorithm for use in prostate image-guided adaptive radiotherapy is presented in a coherent mathematical framework. The registration algorithm is based on a global rigid transformation combined with a series of local injective non-rigid multi-resolution cubic B-spline Free Form Deformation (FFD) transformations.(More)
Many current image-guided radiotherapy (IGRT) systems incorporate an in-room cone-beam CT (CBCT) with a radiotherapy linear accelerator for treatment day imaging. Segmentation of key anatomical structures (prostate and surrounding organs) in 3DCBCT images as well as registration between planning and treatment images are essential for determining many(More)
PURPOSE To develop an accurate, fast, and robust algorithm for registering portal and computed tomographic (CT) images for radiotherapy using a combination of sparse and dense field data that complement each other. METHODS AND MATERIALS Gradient Feature Weighted Minimax (GFW Minimax) method was developed to register multiple portal images to(More)
This paper presents a novel free-form deformation registration algorithm with non-rigid constraints to capture the transformation between the planning day and treatment day CT images used for external beam radiotherapy for prostate cancer. The algorithm is constrained to the predetermined motion of a segmented organ, which is described by an injective(More)
A constrained non-rigid registration (CNRR) algorithm for use in updating prostate external beam image-guided radiotherapy treatment plans is presented in this paper. The developed algorithm is based on a multi-resolution cubic B-spline FFD transformation and has been tested and verified using 3D CT images from 10 sets of real patient data acquired from 4(More)
Image guided external beam radiation therapy (EBRT) for the treatment of cancer enables accurate placement of radiation dose to the cancerous region. However, the deformation of soft tissue during the course of treatment, such as in cervical cancer, presents significant challenges. Furthermore, the presence of pathologies such as tumors may violate(More)