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In times of mass emergency, vast amounts of data are generated via computer-mediated communication (CMC) that are difficult to manually cull and organize into a coherent picture. Yet valuable information is broadcast, and can provide useful insight into time-and safety-critical situations if captured and analyzed properly and rapidly. We describe an(More)
In times of mass emergency, vast amounts of data are generated via computer-mediated communication (CMC) that are difficult to manually collect and organize into a coherent picture. Yet valuable information is broadcast, and can provide useful insight into time-and safety-critical situations if captured and analyzed efficiently and effectively. We describe(More)
The growth and survival of intracellular parasites depends on the availability of extracellular nutrients. Deprivation of nutrients viz glucose or amino acid alters redox balance in mammalian cells as well as some lower organisms. To further understand the relationship, the mechanistic role of L-arginine in regulation of redox mediated survival of(More)
Leishmania contains a concatenated mitochondrial DNA, kDNA. Universal minicircle sequence binding protein (UMSBP), a mitochondrial protein, initiates kDNA replication by binding with a conserved universal minicircle sequence (UMS) of kDNA. Here, we describe first time in L. donovani the regulation of DNA binding activity of UMSBP and the role of UMSBP in(More)
Reactive oxygen and nitrogen species (ROS and RNS) produced by the phagocytic cells are the most common arsenals used to kill the intracellular pathogens. However, Leishmania, an intracellular pathogen, has evolved mechanisms to survive by counterbalancing the toxic oxygen metabolites produced during infection. Polyamines, the major contributor in this(More)
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