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Phenanthroline Derivatives with Improved Selectivity as DNA‐Targeting Anticancer or Antimicrobial Drugs
The absence of antibacterial activity of [PtL1Cl2] removes the detrimental effect of phenanthrolines toward intestinal flora, suggesting a highly promising new strategy for the development of anticancer drugs with reduced side effects. Expand
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
A proof-of concept study results demonstrate CMLD-2 represents a promising HuR-targeted therapeutic class that with further development could lead to advanced preclinical studied and ultimately for lung cancer treatment. Expand
N‐Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
The effort toward identifying small‐molecule inhibitors of this target through structure–activity relationship optimization studies led to the identification of several potent analogues around the N‐phenylbenzamide compound series identified by high‐throughput screening. Expand
Microalgae in Aquaculture: A Review with Special References to Nutritional Value and Fish Dietetics
In the present communication an attempt has been taken to review the application of different microalgae in rearing of aquaculture animal especially the fishes. Expand
Synthesis, crystal structure and biological studies of the highly anticancer active compound trans-dichloridobis(4-methyl-2-N-(2-pyridylmethylene)-aminophenol)ruthenium(II)
Abstract A new Ru(II) compound of formula, trans-[RuII(Hpyrimol)2Cl2] (Hpyrimol = 4-methyl-2-N-(2-pyridylmethylene)aminophenol) has been synthesised, starting from Ru(III) chloride and theExpand
The Square-Planar Cytotoxic [CuII(pyrimol)Cl] Complex Acts as an Efficient DNA Cleaver without Reductant
Chemical nucleases based on the transition-metal ions cleave DNA hydrolytically and/or oxidatively, with or without added reductant. We report here the novel DNA cleavage properties of the highlyExpand
Discovery, Synthesis, and Optimization of Diarylisoxazole‐3‐carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
The therapeutic potential and in vivo efficacy of one of the most potent analogues, N‐(3‐chloro‐2‐methylphenyl)‐5‐(4‐fluoro‐3‐hydroxyphenyl)isoxazole‐ 3‐carboxamide (60), was validated in a biologically relevant zebrafish model of collagen VI congenital muscular dystrophies. Expand
Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: DNA and protein binding studies.
The combined effect of several binding modes towards different bio-molecules is elucidated, providing a rationale for their in vitro activity profile. Expand
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
An inhibitor to the RNA-binding protein HuR, KH-3, is identified that disrupts the interaction between HuR and target RNAs and inhibits human cancer growth and metastasis in mouse xenograft assays. Expand
Composite algal supplementation in nutrition of Oreochromis mossambicus
35 % supplementation of conventional feed with composite algal mix can be used in mossambique tilapia diet and fish fed with VAF showed an increased growth performance, feed efficiency and nutrient utilisation compared to 0 % and 100% supplemented diets. Expand