Subrata Chowdhury

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Programmed death-ligand 1(PD-L1) expression on tumor cells is emerging as a potential predictive biomarker in anti-PD-L1 directed cancer immunotherapy. We analyzed PD-L1 expression in papillary thyroid carcinoma (PTC) and its variants and determined its prognostic potential to predict clinical outcome in these patients. This study was conducted at an(More)
IGF-I is normally produced from hepatocytes and other sources, stimulates protein synthesis, cell survival, and proliferation through receptor-mediated activation of phosphatidylinositol 3-kinase and MAPK, and targets specific molecules within the pancreatic islet cells. The current study was designed to identify novel targets that may mediate its pro-islet(More)
Reg family proteins have been implicated in islet β-cell proliferation, survival, and regeneration. The expression of Reg3β (pancreatitis-associated protein) is highly induced in experimental diabetes and acute pancreatitis, but its precise role has not been established. Through knockout studies, this protein was shown to be mitogenic, antiapoptotic, and(More)
Poly(ADP-ribose) polymerase (Parp) 1 is a key regulator of cell death, its inhibition prevented streptozotocin-induced diabetes and attenuated caerulein-induced acute pancreatitis. Reg family proteins are significantly induced by Parp1 inhibitor, experimental diabetes and/or acute pancreatitis. We propose that Reg proteins are involved in the protection of(More)
i) After analyzing the enlarged digital versions of Fig. 5A andB, we do not agree with the authors’ conclusion that INS-1 cells had positive expression of 11β-HSD1 mRNA and protein; there was hardly any detectable protein/mRNA band in the Western blot and RT-PCR gel image. More troubling evidence was from Fig. 6A vs. Fig. 6B showing an approximately 27-fold(More)
Murine regenerating (mReg) genes have been implicated in preserving islet cell biology. Expanding on our previous work showing that overexpression of mReg2 protects MIN6 insulinoma cells against streptozotocin-induced apoptosis, we now demonstrate that mReg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis and protects MIN6(More)
We have reported a high expression of IGF-I in pancreatic islet β-cells of transgenic mice under the metallothionein promoter. cDNA microarray analysis of the islets revealed that the expression of 82 genes was significantly altered compared to wild-type mice. Of these, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which is responsible for the conversion(More)
We have reported earlier that murine-regenerating gene mReg2 protects MIN6 mouse insulinoma cells from ER stress and caspase-mediated apoptosis. In apoptotic cells, DNA damage is induced by the nuclear translocation of mitochondrial apoptosis-inducing factor (AIF). Here we tested the hypothesis that mReg2 may regulate Scythe and/or hsp70 which influence the(More)
Long term administration of aspirin show efficacy in prevention of colon cancer and drug action is dependent on its interaction with nutrients. This study is aimed at assessing the role of the interaction between a Nigerian-like diet (NLD) or Western-like diet (WLD) and aspirin on energy metabolism and ATPases in early colon carcinogenesis. We observed that(More)
This paper presents the design architecture of distributed security cluster of computers to be saved from the malicious attacks of intruders. Intrusion detection has traditionally been performed at the operating system (OS) level by comparing expected and observed system resource usage. OS intrusion detection systems (OS IDS) can only detect intruders,(More)