Subramanian Mahadevan

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We have evaluated a new set of primers (TRC(4)) in comparison with the IS6110 primers commonly used in PCR to detect tuberculous meningitis among children. The levels of concordance between the results of IS6110 PCR and TRC(4) PCR with cerebrospinal fluid specimens from patients with clinically confirmed tuberculous meningitis were 80 and 86%, respectively.(More)
OBJECTIVES To evaluate clinical outcome and factors affecting outcome in children with snake envenomation. DESIGN Prospective observational study. SETTING Paediatric intensive care unit of a tertiary care teaching hospital in India. PATIENTS We prospectively enrolled children ≤12 years of age admitted to our hospital with a definitive history of snake(More)
BACKGROUND Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorder with a prevalence of 8-12%. Even though psychostimulants remain the treatment of choice, its cost and availability in developing countries limits the usage of the drug. In view of free availability and low cost, a Randomized controlled study(More)
Chanarin-Dorfman syndrome (CDS) is a rare nonlysosomal neutral lipid storage disorder characterized by congenital ichthyosis, lipid vacuoles in leukocytes (Jordan's anomaly), and hepatomegaly. The authors herein report an 18-month-old boy with ichthyosis and hepatomegaly diagnosed with CDS and confirmed to have a novel c.506-3C>G mutation in the(More)
OBJECTIVE To identify causative bacteria from cerebrospinal fluid (CSF) of children with meningitis and analyse various clinical and laboratory parameters. METHODS Over a 20 month period, September 1994 to April 1996, one hundred episodes of acute bacterial meningitis in children aged 1 month-12 years were studied in a tertiary urban hospital in South(More)
OBJECTIVE To assess the efficacy of combined use of scorpion antivenom (SAV) with prazosin, compared with prazosin alone in children with Mesobuthus tamulus scorpion envenomation. STUDY DESIGN Randomised controlled trial. SETTING A tertiary care hospital in south India. PATIENTS 50 children with definite history and/or systemic manifestations of(More)
OBJECTIVE To identify the pattern of intracranial structural lesions in developmentally normal children with partial motor seizures by computed tomography and to monitor the behavior of single ring enhancing lesion (SREL) after a period of time with or without treatment. METHODS Consecutive developmentally normal children between one year and twelve years(More)
OBJECTIVE To evaluate the applicability of Keith Edwards scoring system for the diagnosis of childhood tuberculosis. METHODS One hundred and one children aged 2 months to 12 years who fulfilled the inclusion criteria were evaluated with Keith Edwards score. The diagnosis of tuberculosis by Keith Edwards score and the definitive reference were compared. (More)