Subhramay Chaudhury

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Transcriptional and post-transcriptional events involved in the induction of sodium potassium adenosine triphosphatase (Na+,K(+)-ATPase) by thyroid hormone (T3) were investigated. In vitro transcription of nuclei isolated from cerebra of 5- and 15-day-old normal and hypothyroid rats showed that transcription of all alpha mRNA isoforms (alpha 1, alpha 2 and(More)
A genome-wide association study was carried out in 1020 case subjects with recurrent early-onset major depressive disorder (MDD) (onset before age 31) and 1636 control subjects screened to exclude lifetime MDD. Subjects were genotyped with the Affymetrix 6.0 platform. After extensive quality control procedures, 671 424 autosomal single nucleotide(More)
In the developing brain the active neurite outgrowth during the early phase of synaptogenesis is associated with a thyroid hormone dependent expression of tubulin and actin. In this study, the molecular mechanism of thyroid hormone (TH) action on actin and tubulin gene expression in the developing rat brain has been investigated by comparing the steady(More)
Developmental alterations in the expression of glial fibrillary acidic protein (GFAP) and alpha-tubulin were examined at the level of mRNA and protein in human fetal brain between weeks 13-23 of gestation. Except for a transient increase at week 15, GFAP expression in the cytoskeletal (CSK) fraction was low until week 17, when it increased steadily to week(More)
In the developing rat cerebrum, the level of different isoforms of Na-K-ATPase mRNA increases significantly during the first three postnatal weeks, which represent the critical period of synaptogenesis and myelination-the two thyroid hormone-sensitive maturational events. To determine the possible functional relationship of these isoforms with maturational(More)
Intellectual disability (ID) is of major concern throughout the world, though in ~40% of cases etiology remains unknown (idiopathic ID or IID). Cognitive impairment and behavioral problems are of common occurrence in these subjects and dopamine is known to play an important role in regulating these traits. In the present study the role of functional(More)
The relative sensitivity of the two isotypes of actin mRNA (beta and gamma) to thyroid hormone (T3) was examined by comparing the steady state levels of these mRNAs with their rates of transcription in cerebra from normal and hypothyroid rats of different ages, covering the period of synaptogenesis (days 1-20 postnatal). Hypothyroidism was associated with a(More)
In cultures of neonatal rat brain cells, labeled with 35S-methionine in the presence or absence of triiodothyronine (T3), the hormone promoted a significant enhancement of labeled tubulin and actin in the insoluble fraction (30,000 g pellet) of cell homogenate. To identify the specific sub-cellular fraction associated with this induction, organ cultures of(More)
Studies on the interaction of FITC-tubulin and 125I-tubulin with isolated plasma membrane of neural cells and with primary cultures of neuronal (N) and glial (G) cells of rat brain demonstrate the presence of specific, saturable, high affinity tubulin binding sites in these cells. The positive fluorescence of live unfixed primary cultures of N and G cells(More)