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BACKGROUNDS Human schistosomiasis is caused by schistosome, with annual loss of over 70 million disability adjusted life years in the world. China is endemic with Schistosoma japonicum and large-scale chemotherapy with praziquantel has become the mainstay of control in China since 1990s. However, the control effects of mass treatment in the field have been(More)
Metabolism-mediated drug adverse effects (e.g., drug–drug interaction, bioactivation, etc.) strongly limit the utilization of clinical drugs. The present study aims to predict the metabolic capability of cytochrome P450 (CYP) 3A4 toward pazopanib which is an excellent drug exhibiting therapeutic role toward various cancers especially for ovarian cancer.(More)
OBJECTIVE To analyze the risk factors related to survival time of advanced non-small cell lung cancer (NSCLC) and to establish a prediction model on survival time. METHODS From 2004 - 2006, 184 patients with advanced NSCLC were enrolled in the Affiliated Hospital to the Nantong Medical College. Related risk factors were analyzed, using the Buckley-James(More)
The chronobiology of cercarial emergence appeared to be a genetically controlled behavior, adapted to definitive host species, for schistosome. However, a few physiological and ecological factors, for example the change of photoperiod, were reported to affect the rhythmic emergence of cercariae. Therefore, the effect of photoperiod change on cercarial(More)
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